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Carole

My research interest  is directed towards the multidimensional description and understanding of biological systems. We develop microfluidics-based biosystems to catch and reproduce biological features: hierarchical organization, function and dynamics. This is based on expertise in chemical-physics of biomolecules and biopolymers self-assembly for biomaterials engineering and expertise in nano/microfabrication for biosystems engineering at the Department of Chemistry at ENS (Microfluidics group).

News and highlights

We obtained funding from the ANR to work on the vascularization of 3D skin models.

Collaboration with Laurent Muller @ Collège de France.

Zixu WANG joined the group with a Chinese scholarship to complete a doctoral thesis on the impact of connective tissue topology on the migratory behavior of tumor cancer cells.

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We used microfabricated supports to control the size of tumor spheroids from human ovarian cancer cells. Then, the spheroids were placed on a collagen-based support, which successfully induced the invasion of cancer cells. The use of culture supports that can be easily incorporated into microfluidic chips makes this invasion assay a unique tool for studying collective migratory behaviors in different contexts, typically organogenesis and cancer.

See our preprints. C. Chen, Y. He, E. Lopez, F. Carreiras, A. Yamada, M.-C. Schanne-Klein, A. Lambert, Y. Chen,* C. Aimé* _ Preprint doi.org/10.1101/2021.11.24.469887