High-Grade Serous Ovarian Cancer (HGSOC, hereafter abbreviated as OC) is the fifth most common cause of cancer among women. Therapeutic options combine surgery, chemotherapy and rarely radiotherapy, but a lack of screening methods for early-stage detection, high drug resistance and failure of immunotherapy lead to high relapse rates (average every 2 years) and account for a high mortality rate (50% survival 5 years after diagnosis). This calls for new predictive tools and the development of human-derived tumor-on-chip models.
Recently, we have made remarkable advances on the impact of the ECM on the fate of ovarian cancer cells by decoupling stiffness, rigidity and composition of the ECM (ACS Biomater Sci Eng. 2022). One step further, we have uncoupled the impact of ECM from flow-induced shear stress (Adv Healthc Mater. 2024).
Meanwhile, we are working with oncologists from Gustave Roussy cancer hospital and opticians at Laboratory for Optics and Biosciences (Ecole Polytechnique, Palaiseau) to develop advanced imaging methods to identify ECM patterns in patients who respond and do not respond to treatments.
Collaborators
Marie-Claire Schanne-Klein
CNRS researcher, Laboratory for Optics and Biosciences, Ecole Polytechnique
Alexandra Leary
Oncologist, Institut Gustave Roussy
Ambroise Lambert
Assistant professor, ERRMECe laboratory, Cergy Pontoise University
Zixu Wang
PhD candidate, PASTEUR, Chemistry Department, ENS
Yuehu Zhang
PhD candidate, PASTEUR, Chemistry Department, ENS
Xinyue Lan
PhD candidate, PASTEUR, Chemistry Department, ENS
Publications
Chen, C., Boché, A., Wang, Z., Lopez, E., Peng, J., Carreiras, F., Schanne-Klein, M.-C., Chen, Y., Lambert, A., Aimé, C. The balance between shear flow and extracellular matrix in ovarian cancer-on-chip. Adv Healthc Mater. 2024, 2400938.
Lopez, E., Kamboj, S., Chen, C., Wang, Z., Kellouche, S., Leroy-Dudal, J., Carreiras, F., Lambert, A., Aimé, C. In vitro models of ovarian cancer: bridging the gap between pathophysiology and mechanistic models. Biomolecules, 2023, 13, 103.
Chen, C., Ibrahim, Z., Marchand, M. F., Piolot, T., Kamboj, S., Carreiras, F., Yamada, A., Schanne-Klein, M.-C., Chen, Y., Lambert, A., Aimé, C. 3D collagen topology shapes cell morphology, beyond stiffness. ACS Biomater Sci Eng. 2022, 8, 5284-5294.
Chen, C., He, Y., Lopez, E., Carreiras, F., Yamada, A., Schanne-Klein, M.-C., Lambert, A., Chen, Y., Aimé, C. High-throughput tuning of ovarian cancer spheroids for on-chip invasion assays. Micro and Nano Engineering 2022, 15, 100138.
Carole Aimé 