Research
Ovarian cancer-on-chip
Recently, we have made remarkable advances on the impact of the ECM on the fate of ovarian cancer cells by decoupling stiffness, rigidity and composition of the ECM (ACS Biomater Sci Eng. 2022). One step further, we have uncoupled the impact of ECM from flow-induced shear stress (Adv Healthc Mater. 2024). See more here!
Angiogenesis-on-chip
Using microfabricated and micropatterned patches, we have developed an interface enabling high-resolution 3D imaging and quantitative 3D analysis of angiogenesis under controlled microenvironmental conditions. See more here!
Muscle-on-chip
Ovarian cancer-on-chip
High-Grade Serous Ovarian Cancer (HGSOC, hereafter abbreviated as OC) is the fifth most common cause of cancer among women. Therapeutic options combine surgery, chemotherapy and rarely radiotherapy, but a lack of screening methods for early-stage detection, high drug resistance and failure of immunotherapy lead to high relapse rates (average every 2 years) and account for… Continue reading Ovarian cancer-on-chip
Angiogenesis-on-chip
Angiogenesis is a fundamental process in the development and progression of many tumor and ischemic cardiovascular pathologies. Commonly used angiogenesis assays are two-dimensional, do not take into account the variability of microenvironments encountered and are unable to analyze microvascular perfusion. Using microfabricated and micropatterned patches, we have developed an interface enabling high-resolution 3D imaging and… Continue reading Angiogenesis-on-chip
Muscle-on-chip
Collaborators Christophe Hélary CNRS research engineer, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Sorbonne University Léna Villerabel PhD candidate, LCMCP, Sorbonne University / PASTEUR, Chemistry Department, ENS Maxime Mauviel Postdoctoral researcher, PASTEUR, Chemistry Department, ENS
Carole Aimé 